Middlesex tells the story of Calliope Stephanides, a hermaphrodite who is raised a girl and remains essentially unaware of her unusual genitalia (and, more generally, 'her' male identity) until she reaches puberty. The story is narrated by Cal, the intelligent, relatively well-adjusted man Calliope grows into. As he puts it at one point in the novel, "hermaphrodites are people too" - people with families, jobs, and lost loves. Thus in order to understand who he is, readers must first understand where he came from. Eugenides does an amazing job of creating Calliope/Cal's character in such a way that readers (or at least this reader) see his status as a hermaphrodite as only part of who he is. Cal's dual genitalia is not solely and immediately gross or freakish, so much as it is his personal burden - his version of that thing everyone bears in his or her own way.
Middlesex is also a story about family history and DNA. More specifically, it explores the tension between preordained fate and self-determination. How much are we the products of our parents, grandparents, etc, both genetically and culturally? Can this ever be truly at odds with or different from the lives we choose for ourselves? Does Cal really choose to live as a man, or was the choice made for him generations ago in a small village in Greece? I adore novels that can raise questions such as these without sounding self-righteous and preachy. Middlesex does so beautifully.
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